Cinnamon and ginger extracts attenuate diabetes-induced inflammatory testicular injury in rats and modulating SIRT1 expression

The current study aimed to evaluate the efficacy of simultaneous administration Zingiber officinale (ginger) and Cinnamomum cassia (cinnamon) extracts in mitigating testicular changes associated with diabetes mellitus rats investigate its molecular mode action. After induction using streptozotocin, 36 male were divided six groups namely control, diabetic, metformin-treated, cinnamon-treated, ginger-treated combined, each group having 6 rats. Fasting blood glucose, serum insulin, testosterone was measured. Expression inflammatory mediators; tumor necrosis factor-alpha (TNF-α), Nuclear factor kappa B (NF-κB) Sirtuin 1 (SIRT1) assessed tissue. Histopathological testis observed spermatogenesis apoptosis immunohistochemically. histological biochemical studies untreated confirmed structural testes induced by diabetes. Oral ginger cinnamon increased insulin level significantly while glucose decreased diabetic rats, improving considerably. Joint intake antihyperglycemic, antioxidant anti-inflammatory effects markedly injury compared either them. SIRT1 expression plus cinnamon-treated These results indicate that when administrated together, synergistically enhanced antioxidant, antiapoptotic antihyperglycemic effect comparable metformin. combination also upregulated testis.